I just received a request for a rewrite on the ending to one of my stories that touches upon a setting point. Normally, this wouldn't be a problem: if I agreed with the request, I wouldn't mind doing the bodywork throughout the story to alter the ending. However, in this case, I was working in a pre-established setting where I've written other works - including the last novel I abandoned; I was about 57k into it and hadn't even hit what I envisioned as the main action of the novel - and the setting point holds up as important for future ideas.
Now, I was able to make an edit that I think moves in the right direction. Do I think the setting point harms this individual story? No. It adds a tinge of realism to the conclusion. Sometimes the world is bigger than we are. But I thought it was interesting that this stricture came up for me, especially as I usually do hop to other worlds. We'll see.